Uncontrolled diabetes mellitus predisposes to which complication?

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High blood glucose over time damages nerves and blood vessels and weakens immune defenses. This combination sets the stage for skin ulcers. Peripheral neuropathy dulls sensation in the feet, so minor injuries go unnoticed and can worsen into ulcers. At the same time, microvascular disease limits blood flow and oxygen to tissues, slowing healing. Hyperglycemia also impairs immune cell function, increasing infection risk and further delaying repair. Together, these factors make uncontrolled diabetes a leading cause of skin ulcers, especially on the feet. While hypertension, anemia, or hair loss can occur with diabetes in different contexts, they don’t explain the direct, ulcer-prone problems seen with poor glucose control.