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Multiple Choice

Suppurative osteomyelitis in intravenous drug users most often involves which pathogen?

Infection of bone in intravenous drug users is often tied to direct inoculation from non-sterile injection practices. Pseudomonas aeruginosa is a classic offender here because it thrives in contaminated water, diluents, and injection paraphernalia, and it can seed bone after puncture injuries. This environmental exposure makes it the most likely offender in this population. While Staphylococcus aureus is a common cause of osteomyelitis in many patients, the IV drug use context elevates the likelihood of Pseudomonas due to the specific way infections are acquired in this group.

Infection of bone in intravenous drug users is often tied to direct inoculation from non-sterile injection practices. Pseudomonas aeruginosa is a classic offender here because it thrives in contaminated water, diluents, and injection paraphernalia, and it can seed bone after puncture injuries. This environmental exposure makes it the most likely offender in this population. While Staphylococcus aureus is a common cause of osteomyelitis in many patients, the IV drug use context elevates the likelihood of Pseudomonas due to the specific way infections are acquired in this group.